Is Fenbendazole Cancer Treatment Effective?
A popular alternative cancer treatment known as the Joe Tippens Protocol, involves taking fenbendazole (or Panacur C) at 222 mg per day seven days a week. Despite the fact that this medication is generally tolerated well by humans, there are few studies on its effectiveness against cancer, and some research has found it to be ineffective.
Benzimidazole carbamate, which is the active component of fenbendazole, is commonly used to treat parasites and worms in animals (roundworms, hookworms, whipworms, and some tapeworms) and can be purchased over-the-counter at most drug stores in the form of oral granules or liquid suspension. However, this medication is also gaining popularity as a cure for cancer due to its purported anti-cancer properties.
The researchers found that fenbendazole (FZ) significantly inhibited cell growth in colorectal cancer cells as well as patient-derived colon cancer organoids. This effect was mediated through several mechanisms including the inhibition of glucose uptake, oxidative stress and apoptosis. In particular, FZ exposure led to a decrease in cyclin B1 levels and an increase in apoptosis in both 5-FU-sensitive SNU-C5 and SNU-C5/5-FUR colorectal cancer cells. FZ-exposure also reduced expression of glut-4 transporter, hexokinase II, and p53 in both CRC cell lines.
Additionally, fenbendazole caused increased expression of autophagy markers such as Beclin-1 and LC3-I in both CRC cells. Lastly, fenbendazole exposure led to the accumulation of iron and induction of ferroptosis which is a type of lipid-mediated cell death characterized by lipid peroxidation and mitochondrial injury. fenben cancer treatment